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  1. Michael A Kamm on behalf of the InControl study authors
  1. Correspondence to Michael A Kamm, StVincent's Hospital, Victoria Parade, Fitzroy, Melbourne 3065, Australia; mkamm{at}unimelb.edu.au

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We are pleased to receive the comments from Professor Benini et al1 about our article.2

Contrary to their initial comments, in our view this study was very much designed to reflect ‘real-life’ constipated patients, and to have broad clinical relevance.

Reduced bowel frequency is just one of the symptoms of constipation, and is not a requisite for the diagnosis of constipation, as recognised by the Rome criteria3 and many studies that have evaluated the symptoms in these patients. Many patients have a normal bowel frequency, but complain of …

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