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Treatment of Helicobacter pylori infection
  1. Luigi Gatta1,2,
  2. Francesco Di Mario2,
  3. Dino Vaira3
  1. 1Gastroenterology and Endoscopy Unit, Versilia Hospital, Lido di Camaiore, Italy
  2. 2Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Parma, Italy
  3. 3Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
  1. Correspondence to Luigi Gatta, Section of Gastroenterology, Department of Clinical Science, University of Parma, via Gramsci 14, Parma 43100, Italy; gattaluigi{at}

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We read with great interest the article of Liou et al published in Gut,1 and we would like to highlight some points.

First, the authors stated that patients were considered positive only if two out of three tests performed (ie, rapid urease test, histology and culture) were positive. However, due to its high specificity (almost 100%),2 a positive culture alone can be considered a marker of Helicobacter pylori infection, as stated by guidelines for clinical trials on …

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    J-M Liou J-T Lin C-Y Chang M-J Chen Y-C Lee M-S Wu