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We greatly appreciated Dr Gatta and colleagues'1 interest and valuable comments to our study published in this journal.2 Our response to their comments were as follows. First, 7 out of the 1173 patients were excluded because of positive culture alone in the screening for eligibility. Second, the successful rate of culture in naïve patients was approximately 74.5% in this study. Although the specificity of culture was high (near 100%), the sensitivity was usually lower (ranged from 55% to 90%) in the literature.3 Factors that might affect the sensitivity of culture for Helicobacter pylori included (1) a delay in transporting the specimen to the laboratory, (2) insufficient number of biopsied specimens, (3) exposure of the bacteria to an aerobic environment, (4) the presence of gastric …
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