Article Text

PDF
Kupffer cell activation and portal hypertension
  1. Christian J Steib
  1. Department of Medicine II, Liver Center Munich, University of Munich, Grosshadern, Munich, Germany
  1. Correspondence to Christian J Steib, Klinikum Grosshadern, Department of Medicine II, Liver Center Munich (LCM), Ludwig-Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany; christian.steib{at}med.uni-muenchen.de

Statistics from Altmetric.com

Kupffer cells (KC), the resident liver macrophages, constitute the liver sinusoids together with other cells such as sinusoidal endothelial cells, hepatic stellate cells, liver-specific natural killer cells and dendritic cells. KC account for approximately 10–15% of the total liver cell population and represent 80–90% of tissue macrophages in the reticuloendothelial system. KC represent an important component of innate immunity.1 2 One characteristic of innate immunity is the rapid response to potentially dangerous stimuli. This suggests a central role of the liver in systemic and regional immune response, because KC come in contact with all the microbiological debris from the gastrointestinal tract reaching the liver via the portal vein.3

KC express the scavenger receptor CD163; CD163 is involved in the clearance and endocytosis of the haemoglobin–haptoglobin complex.4 Once erythrocytes or the haemoglobin–haptoglobin complex has been taken up by KC, the heme delivered from haemoglobin is degraded by heme oxygenases. The isoform heme oxygenase-1 is only observed in KC and its expression and the consecutive bilirubin production increases immediately after exposure to damaged erythrocytes. Heme oxygenase-1 and CD163 expression increase after exposure to inflammatory stimuli. The interplay of KC, CD163 and heme oxygenase-1 has thus been identified as an important system that is upregulated in inflammatory conditions in order to enhance haemoglobin clearance and heme degradation.5

The interesting study …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles