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A 38 year old Caucasian woman whose father and two brothers had been diagnosed with hereditary haemochromatosis was found to have chronic fatigue and a serum ferritin of 1490 μg/l. Her transferrin saturation was 32% and her full blood count, liver biochemistry, international normalised ratio and C-reactive protein were all normal. She had regular menstrual periods and no other medical history of note. She had no specific risk factors for chronic liver disease, her alcohol consumption was less than 5 units a week and there was no history of receipt of blood transfusion. Clinical examination …
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