Article Text

PDF

Oesophagus
A randomised controlled trial of ALA versus photofrin PDT for high grade dysplasia in barrett's oesophagus
  1. J M Dunn *1,
  2. G D Mackenzie1,
  3. S Thorpe1,
  4. M Austwick1,
  5. C A Mosse1,
  6. D Oukrif2,
  7. A Winstanley2,
  8. M Rodriguez-Justo2,
  9. M R Novelli2,
  10. M R Banks3,
  11. S G Bown1,
  12. L B Lovat1,3
  1. 1National Medical Laser Centre, University College London, London, UK
  2. 2Histopathology, University College London, London, UK
  3. 3Gastroenterology, University College London Hospitals NHS Trust, London, UK

Abstract

Introduction Sodium porfimer photodynamic therapy (sp-PDT) is a licensed minimally invasive treatment for Barrett's Oesophagus (BO) with high grade dysplasia (HGD). Complete reversal (CR)-HGD is 50% at 5 years. sp-PDT is associated with a significant risk of strictures and prolonged photosensitivity up to 3 months. 5 aminolaevulinic acid (ALA) is an alternative treatment with 36 h photosensitivity. Non-randomised data suggests 85% CR-HGD and low risk of side effects. The aim of this study was to compare the side effect profile between the drugs and outcomes of therapy.

Methods Single centre randomised controlled trial. Presence of HGD was confirmed on two occasions by two specialist GI pathologists. All patients had Endoscopic Ultrasound and endoscopic resection of visible lesions prior to PDT. Stratification was by length of BO (<>6 cm) and extent of dysplasia. Standard protocols for ALA and sp-PDT were followed. Endoscopic follow-up with 2 cm four-quadrant biopsy was at 6 weeks, 4 months, then annually. All adverse event data were collected.

Results Sixty-four patients were randomised, 34 ALA and 30 sp-PDT. Median follow-up is currently 23 months. Strictures and skin photosensitivity were significantly more common with sp-PDT than ALA-PDT (33% vs 9% and 43% vs 6% respectively) p<0.05. Preliminary outcome data show CR-HGD in 17/34 (50%) with ALA-PDT and 12/30 (40%) with sp-PDT. Overall cancer incidence was 10%, no significant difference between groups. For BO ≤6 cm, using log-rank analysis CR-HGD was more likely with ALA-PDT (78%) than sp-PDT (31%), Ç2 = 4.34, p=0.037. For BO length >6 cm there was no significant difference. Rate of buried glands was significantly higher post PDT (48%) than pre PDT (20%), no significant difference between groups.

Conclusion ALA-PDT has a better risk profile than sp-PDT. In patients with BO length ≤6 cm, preliminary results show ALA-PDT is associated with significantly higher CR-HGD. In longer segments of BO neither PDT drug was sufficiently efficacious to warrant use.

  • Barrett's oesophagus
  • High grade dysplasia
  • Photodynamic therapy

Statistics from Altmetric.com

Footnotes

  • Competing interests J. Dunn: None Declared, G. Mackenzie: None Declared, S. Thorpe: None Declared, M. Austwick: None Declared, C. Mosse: None Declared, D. Oukrif: None Declared, A. Winstanley: None Declared, M. Rodriguez-Justo: None Declared, M. Novelli: None Declared, M. Banks: None Declared, S. Bown: None Declared, L. Lovat Grant/Research Support from: DUSA Pharmaceuticals.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.