Lymphocytic oesophagitis, a condition in search of a disease?
- Jukka Ronkainen1,
- Marjorie M Walker2,
- Pertti Aro3,
- Tom Storskrubb4,
- Nicholas J Talley5,
- Zohreen B Ahmed2,
- Victoria Salter2,
- Michael Vieth6,
- Lars Agréus3
- 1Primary Health Care Center Tornio, Institute of Health Sciences, University of Oulu, Tornio, Finland
- 2Histopathology, Centre for Pathology, Division of Medicine, Imperial College, London, UK
- 3Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
- 4Aspstigen 5, Kalix, Sweden
- 5Health Callaghan, University of Newcastle, Callaghan, New South Wales, Australia
- 6Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
- Correspondence to Dr Marjorie M Walker, Centre for Pathology, Division of Medicine, Imperial College, Histopathology, London, W2 1NY, UK; mm.walker{at}imperial.ac.uk
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Contributors The original study was devised by LA and NJT. JR, PA and TS performed the data collection through questionnaires and performed endoscopies and collated these data. MV, MMW, VS and ZBA devised this arm of the study and performed the histology. All contributed to the manuscript and approved the final draft.
- Accepted 22 February 2012
- Published Online First 5 April 2012
- Gastro-oesophageal reflux disease
- Barrett's oesophagus
- oesophageal reflux
- oesophagitis
- epidemiology
- histopathology
- Helicobacter pylori
- celiac disease
- dyspepsia
- irritable bowel syndrome
- duodenal mucosa
- intestinal mast cells
- T lymphocytes
- Barrett's metaplasia
- Barrett's carcinoma
- gastro-oesphageal junction
- mucosal pathology
- gastritis
- gastric inflammation
- inflammatory bowel disease
- gastrointestinal cancer
- gastric neoplasia
- gastric precancer
There have been conflicting studies on the existence of lymphocytic oesophagitis, first described by Rubio et al in 2006 and characterised by an excess infiltration of intraepithelial lymphocytes (IELs) in the peripapillary fields.1 We therefore read with interest the article by Haque and Genta which states lymphocytic oesophagitis occurs in 0.1% of oesophageal biopsies from a large gastrointestinal pathology practice covering 43 states in the USA.2 Lymphocytic oesophagitis is described in this …
