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Virulence factors or ancestral origin of Helicobacter pylori: which is a better predictor of gastric cancer risk?
  1. Seiji Shiota1,
  2. Osamu Matsunari1,
  3. Masahide Watada1,
  4. Yoshio Yamaoka1,2
  1. 1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita, Japan
  2. 2Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
  1. Correspondence to Professor Yoshio Yamaoka, Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd. Houston, Texas 77030, USA; yyamaoka{at}bcm.tmc.edu or yyamaoka{at}bcm.edu

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We have read the recently published article by de Sablet et al with great interest. The article is well structured and has important findings about the ancestral origin of Helicobacter pylori, which can be used as a predictor of gastric cancer risk.1 de Sablet et al performed multi-locus sequence typing (MLST) to determine phylogeographic variation, which was significantly associated with the different histopathological scores and the prevalence of gastric cancer in the specific regions that they studied. However, we think that the study by de Sablet et al has several limitations.

First, there …

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