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Letter
Hyperplastic polyposis syndrome and the risk of colorectal cancer
  1. Janina Orlowska1,2
  1. 1Histopathology Laboratory, Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education, Warsaw, Poland
  2. 2The Maria Sklodowska - Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland
  1. Correspondence to Janina Orlowska, Histopathology Laboratory, Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education, Oncology Centre, Roentgena 5, Warsaw 02-781, Poland; jorlowska{at}coi.waw.pl

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I read with great interest the two reports by Boparai and coworkers in Gut on the increased risk of colorectal carcinoma (CRC) in 77 hyperplastic/serrated polyposis syndrome (HPS) patients during follow-up1 and in 347 HPS first-degree relatives (FDRs).2 To date, follow-ups have been performed in only 43/308 (14.0%) HPS patients and HPS coexistence with CRC in FDRs has been analysed in only 29/308 (9.4%) HPS patients described up to the end of 2009 (table 1).

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Table 1

CRC in HPS patients in the literature review from 1977 to the end of 2009* in comparison with the studies by Boparai et al in 20101 2

Nevertheless, there are some points to be explained:

  1. The term ‘(sessile) serrated adenoma’ should be abbreviated as SSA, instead of SA (serrated adenoma). SSA, characterised by abnormal …

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