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- Crohn's disease
- single nucleotide polymorphism
- NADPH oxidase
- innate immunity
- p40phox
- inflammatory bowel disease
- immune response
- crohns disease
- cell biology
- autoimmune disease
- immunology
- colon carcinogenesis
- signal transduction
- oxidative stress
- molecular immunology
We read with interest the paper from Muise et al in which they describe a rare variant in the NCF2 gene, which demonstrates a diminished RAC2 binding capacity.1 The NCF2 encoded protein p67phox is one of the components of the NADPH oxidase complex which drives the production of reactive oxygen species (ROS) during the bactericidal response of innate immune cells. Output of disturbed granulocytic ROS as a result of impaired functioning of this enzyme complex has been shown in a number of diseases, including myelodysplasia (MDS) and chronic granulomatous disease.2 3 As Muise and colleagues point out, these diseases have been linked to development of a colitis resembling that seen in Crohn's disease (CD), suggesting a potential role for impaired ROS production in CD pathology.
Genome-wide association studies (GWAS) are a promising tool to identify genetic variants …
Footnotes
Linked article 300078.
Competing interests None.
Ethics approval Ethics approval was provided by the appropriate medical ethical review board of the Erasmus University Medical Center, Rotterdam, the Netherlands.
Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement Authors are prepared to share data as described in the manuscript.