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Letter
Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease
  1. R Somasundaram,
  2. J J Deuring,
  3. C J van der Woude,
  4. M P Peppelenbosch,
  5. G M Fuhler
  1. Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
  1. Correspondence to Dr Gwenny Fuhler, Erasmus University Medical Center Rotterdam, Department of Gastroenterology and Hepatology, Research Laboratory, Room L456, 's Gravendijkwal 230, 3015 CE Rotterdam, Netherlands; g.fuhler{at}erasmusmc.nl

https://doi.org/10.1136/gutjnl-2011-301344

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    We read with interest the paper from Muise et al in which they describe a rare variant in the NCF2 gene, which demonstrates a diminished RAC2 binding capacity.1 The NCF2 encoded protein p67phox is one of the components of the NADPH oxidase complex which drives the production of reactive oxygen species (ROS) during the bactericidal response of innate immune cells. Output of disturbed granulocytic ROS as a result of impaired functioning of this enzyme complex has been shown in a number of diseases, including myelodysplasia (MDS) and chronic granulomatous disease.2 3 As Muise and colleagues point out, these diseases have been linked to development of a colitis resembling that seen in Crohn's disease (CD), suggesting a potential role for impaired ROS production in CD pathology.

    Genome-wide association studies (GWAS) are a promising tool to identify genetic variants …

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    Footnotes

    • Linked article 300078.

    • Competing interests None.

    • Ethics approval Ethics approval was provided by the appropriate medical ethical review board of the Erasmus University Medical Center, Rotterdam, the Netherlands.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Data sharing statement Authors are prepared to share data as described in the manuscript.

    Linked Articles

    • Inflammatory bowel disease
      NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2
      Aleixo M Muise Wei Xu Cong-Hui Guo Thomas D Walters Victorien M Wolters Ramzi Fattouh Grace Y Lam Pingzhao Hu Ryan Murchie Mary Sherlock Juan Cristóbal Gana NEOPICS Richard K Russell Michael Glogauer Richard H Duerr Judy H Cho Charlie W Lees Jack Satsangi David C Wilson Andrew D Paterson Anne M Griffiths Mark S Silverberg John H Brumell
      Gut 2011; 61 1028-1035 Published Online First: 07 Sep 2011. doi: 10.1136/gutjnl-2011-300078
    • PostScript
      The Authors' reply
      Aleixo M Muise Ramzi Fattouh Grace Y Lam Sandeep Dhillon John H Brumell
      Gut 2011; 61 1097-1098 Published Online First: 22 Nov 2011. doi: 10.1136/gutjnl-2011-301469