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- IBD, inflammatory bowel disease
- Crohn's diseaseChronic Granulomatous disease
- Chronic Granulomatous disease
- reactive oxygen species
- NADPH oxidase complex
- IBD - genetics
- IBD basic research
- IBD clinical
- bacterial pathogenesis
- cell biology
- cellular immunity
We read with interest the letter by Somasundaram et al1 in response to our paper ‘NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2’ that further demonstrates the importance of the NADPH oxidase complex genes in the pathogenesis of Crohn's disease. Their letter provides interesting confirmatory data that complement our findings, which already clearly demonstrate the role of the NADPH oxidase complex in inflammatory bowel disease (IBD).2 However, there are a number of important issues that require further clarification.
Somasundaram et al suggest that our study did not show the association between reactive oxygen species (ROS) production and IBD.1 Our study clearly shows that ROS production is important …
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