Prothrombin index slope is an early prognostic marker in patients with severe acute liver diseases
- Bertrand Nalpas1,2,
- Claire Francoz3,
- Philippe Ichaï4,
- Laure Jamot5,
- Jamila Faivre6,7,
- Sara Lemoinne4,
- Didier Samuel4,6,
- François Durand3,8,
- Jacques Bernuau3,
- Christian Bréchot5,6,
- Paul Amouyal5,
- Gilles Amouyal5
- 1U1016, Inserm, Paris, France
- 2Unité d'Hépatologie, Hôpital Cochin, Paris, France
- 3Pôle des maladies de l'appareil digestif, Service d'Hépatologie, Unité de réanimation hépato-digestive, Hôpital Beaujon, Clichy, France
- 4Centre de Soins Intensifs Hépatique, Centre Hépato-Biliaire, Hôpital Paul Brousse, Villejuif, France
- 5Alfact Innovation, Paris, France
- 6U785, Inserm, Villejuif, France
- 7Faculté de Medecine, Université Paris sud, Villejuif, France
- 8U773, Inserm, Clichy, France
- Correspondence to Dr Gilles Amouyal, Alfact Innovation, 320 rue Saint Honoré, Paris 75001, France; gamouyal{at}orange.fr
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Contributors BN, CF, PI and LJ are co-first authors. B Nalpas was in charge of performing the statistical analyses and writing the paper, and took part in the initial reflexion for constructing the study. C Francoz and F Durand were in charge of patients at Beaujon Hospital. P Ichai and D Samuel were in charge of patients at Paul Brousse Hospital. L Jamot was in charge of collecting the data and writing the paper, and took part in the initial reflexion for constructing the study. S Lemoinne was in charge of collecting data at Paul Brousse Hospital. J Bernuau was in charge of reviewing the data of all the patients and participated in the paper writing. J Faivre, C Béchot, P Amouyal and G Amouyal initiated this study and took part in the initial reflexion for constructing the paper as well as for the writing.
In a recent study published in Gut, Mura et al1 followed up patients with cirrhosis …
