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Viral hepatitis
PMO-170 Prevalence of hepatitis E in New York among HIV negative chronic liver disease population “is it an innocent bystander”
  1. P Basu1,2,
  2. T Nair3,
  3. S Farhat3,
  4. M Jafri4,
  5. K Mittimani3,
  6. N James Shah3,
  7. L Ang3
  1. 1Department of Gastroenterology and Hepatology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
  2. 2Gastroenterology, North Shore University, New York, USA
  3. 3Internal Medicine, North Shore University, New York, USA
  4. 4Internal Medicine, NYMC Richmond, New York, USA

Abstract

Introduction Hepatitis E is essentially an oral fecal infection with high prevalence in developing countries. There is limited data available on its prevalence in Urban US. The study evaluates the prevalence of hepatitis E antibody IgG and IgM in New York in patients with chronic liver disease.

Methods 440 (n=440) were divided into two groups: group A; control 140 patients without any stigmata of liver disease. Group B, 300 patients with history of liver disease including hepatitis B 125/300 (41%), Chronic hepatitis C 60/300 (20%), fatty liver 70/300 (23%), Alcoholic liver disease 29/300 (10%), HBV HCV co infection 9/300 (3%), auto immune hepatitis 2/300 (0.6%), PBC /PSC 5/300 (2%). HEV antibody IGM and IGG were measured with HEV genotyping. 22/300 (7%) patients were liver transplant recipients, 6/300 (2%) patients were kidney transplant recipients. 43/300 (14%) patients were Intra venous Drug Abuser. 20/300 (7%) received Blood products.

Results History and genotypic characteristics

CharacteristicsChronic hepatitis CChronic hepatitis BFatty liverAlcoholic liver disease
IVDU36/43 (83%)7/43 (16%)NANA
Promiscuity23/42 (52%)10/42 (23%)NA9/42 (2!%)
Transfusion6/20 (30%)14/20 (70%)NANA
Genotype
 G12/30 (7%)60/69 (87%)3/10 (30%)1/13 (7%)
 G21/30 (3%)8/69 (11%)3/10 (30%)4/13 (30%)
 G326/30 (87%)1/69 (1%)4/10 (40%)8/13 (62%)
 G41/30 (3%)NANANA
 G4NANANANA

Conclusion Results: Group (A) HEV IgG positive 13% (18/140), Group B HEV IgG positive 40.6% (122/300) including 3.7% (4/122) having both IgM and IgG positive. The prevalence of HEV IgG was 54% (12/22) in the liver transplant recipient group and 33% (2/6%) kidney transplant recipient group. The study demonstrates the prevalence of hepatitis E infection in New York and HEV antibody in CLD. Including transplant donors and recipients. Question remains the impact and progression of acute or chronic liver disease with concomitant HEV in pre, peri, and post liver transplant recipient. Larger study needs to validate.

Competing interests None declared.

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