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Neurogastroenterology and motility
PWE-047 Full thickness small bowel biopsy in gut dysmotility. Case series of eight patients illustrating the benefits as a diagnostic tool
  1. E Harrison1,
  2. J E Martin2,
  3. S C Cooper1
  1. 1Department of Gastroenterology, Dudley Group of Hospitals NHS Foundation Trust, Birmingham, UK
  2. 2Blizard Institute of Cell and Molecular Science Pathology Group, The Royal London Hospital, London, UK

Abstract

Introduction Full thickness small bowel biopsies offer the opportunity to make a definitive diagnosis in patients with gastrointestinal dysmotility. However, our experience suggests that standard histological reporting may fail to achieve this diagnosis. This study compares local diagnoses to those of a national expert.

Methods We retrospectively reviewed eight sequential patients with symptomatic gastrointestinal dysmotility who were reviewed at a tertiary centre having had locally reported full thickness small bowel biopsies. Local histological reports were compared to those of a national expert. Patient notes were reviewed to determine the clinical impact of achieving a definitive diagnosis. Some patients were questioned regarding the impact of their definitive diagnosis.

Results The biopsies of the eight sequential patients had been reported by one of four centres within the West Midlands. All, except one, of these local reports were normal. However, subsequent review of all eight biopsies by the national expert identified pathological changes in all. Diagnoses established included two cases of polyglucosan body myopathy, confirmation of NSAID enteropathy and differing forms of inflammation (eg, lymphocytic plexitis). Establishing these diagnoses enabled accurate prognoses and implementation of subsequent management, including continuation of home parenteral nutrition (HPN, n=6) and consideration for small intestinal transplantation (SIT, n=3). Patients questioned reported additional benefits.

Conclusion Gut dysmotility can be highly symptomatic and debilitating leading to intestinal failure (IF), HPN and SIT. Clinical decisions for consideration for HPN and SIT are complex. Decisions must consider the potential for morbidity and mortality against the potential for improvement in nutritional status, quality of life and survival. A full thickness small bowel biopsy, while invasive, offers opportunity for a definitive diagnosis, and thus a prognosis. Published series report an 81% diagnostic yield for small bowel biopsies in patients with suspected gastrointestinal neuromuscular disorders, when using routine and immunohisto-chemical techniques.1 However, standard histopathological reporting, which is often based on H&E staining alone, has less potential for achieving a diagnosis. This is shown by our study in which a diagnosis was achieved in only 13%. Thus, our study highlights the importance of expert review and demonstrates the importance of achieving a diagnosis for patient and clinician.

Competing interests None declared.

Reference 1. Knowles CH, Veress B, Tornblom H, et al. Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biopsy. Neurogastroenterol Motil 2008;20:774–9.

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