Article Text


Inflammatory bowel disease III
PWE-225 Efficacy of faecal lactoferrin in IBS and IBD: a comparative study
  1. H Jayasena1,
  2. C S Probert2,
  3. P Savage3,
  4. R Greenwood4
  1. 1Department of Gastroenterology, Bristol Royal Infirmary, Bristol, UK
  2. 2Department of Gastroenterology, Royal Liverpool University Hospitals, Liverpool, UK
  3. 3School of Clinical Sciences, University of Bristol, Bristol, UK
  4. 4Research and Development, Bristol Royal Infirmary, Bristol, UK


Introduction Faecal lactoferrin (FL) has been proposed as a non-invasive diagnostic tool in IBD.1 This is the first study conducted in a UK outpatient setting comparing simple colitis index (SCI) for ulcerative colits (UC) and Harvey Bradshaw index (HBI) for Crohn's disease (CD) against FL concentration in IBD and IBS patients.

Methods From an IBD outpatient clinic, stool samples were collected and concurrent disease activity recorded for UC, CD, IBS patients along with samples from healthy volunteers. Using IBD-Scan®, a quantitative ELISA, FL concentration was measured. Each participant's recorded clinical index at time of collection was compared against calculated FL concentration to assess clinical efficacy of FL in determining disease status in IBD and in differentiating IBD from IBS.

Results Spearman's correlation for correlation between LF and clinical score indices: 0.027 (p<0.05).

Conclusion FL is useful in staging of IBD and in differentiating IBD from IBS.

Abstract PWE-225 Figure 1

Lactoferrin plotted on a log scale for UC, CD, IBS and control groups respectively.

Abstract PWE-225 Table 1

Competing interests None declared.

Reference 1. Baveye S, Elass E, Mazurier J, et al. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med 1999;37:281–6.

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