Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system
- 1Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
- 2Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, USA
- 3Division of Gastroenterology, Mayo Clinic, Jacksonville, Florida, USA
- Correspondence to Dr Ikuo Hirano, Professor of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair, Suite 1400, Chicago, IL 60611, USA;
Contributors IH conceived, designed and helped execute the study and drafted the manuscript. NM designed and executed the study. MGH and CT helped with the study design, performed the statistical analyses and drafted the manuscript. NG helped to design the study. SRA helped to conceive and design the study.
- Revised 27 February 2012
- Accepted 8 March 2012
- Published Online First 22 May 2012
Objective Abnormalities are commonly identified during endoscopy in eosinophilic oesophagitis (EoE). There is no standardised classification to describe these features. This study aimed to evaluate the interobserver agreement of a grading system for the oesophageal features of EoE.
Method The proposed system incorporated the grading of four major oesophageal features (rings, furrows, exudates, oedema) and the presence of additional features of narrow calibre oesophagus, feline oesophagus, stricture and crepe paper oesophagus. Endoscopic videos from 25 patients with EoE and controls were reviewed by 21 gastroenterologists. Interobserver agreement was assessed by estimating multi-rater κ and the proportion of pairwise agreement.
Results Using the original grading system, agreement for rings, furrows and exudates was moderate (κ=0.38–0.46, 56–65% agreement) but poor for oedema (κ=0.23, 51% agreement). Identification of narrow calibre oesophagus had fair agreement (κ=0.30, 74% agreement) while feline oesophagus had poor agreement (κ=0.15, 68% agreement). After collapsing the severity grading for oedema and furrows and eliminating poorly performing features of feline oesophagus and narrow calibre oesophagus, a modified grading system demonstrated good agreement for the four major features of EoE (κ=0.40–0.54, 71–81% agreement) and additional features of stricture and crepe paper oesophagus (κ=0.52 and 0.58, 79% and 92% agreement).
Conclusions The proposed system for endoscopically-identified oesophageal features of EoE defines common nomenclature and severity scores for the assessment of EoE disease activity. The system has good interobserver agreement among practising and academic gastroenterologists.
Funding Campaign Urging Research for Eosinophilic Disease Foundation (CURED).
Competing interests None.
Ethics approval Approval was obtained from the Northwestern University Institutional Review Board.
Provenance and peer review Not commissioned; externally peer reviewed.