Gut 62:812-823 doi:10.1136/gutjnl-2012-304356
  • Guidelines

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

Open AccessEditor's Choice
  1. (the Mallorca group)
  1. 1 Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
  2. 2 Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain
  3. 3 Department of Medical Genetics Haartman Institute Biomedicum, University of Helsinki, Helsinki, Finland
  4. 4 Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
  5. 5 Department of Medical Genetics, Complejo Hospitalario de Navarre, Pamplona, Spain
  6. 6 Institute of Human Genetics, University Hospital, Bonn, Germany
  7. 7The Danish HNPCC-Register, Department of Gastroenterology and Clinical Research Center, Copenhagen University Hospital, Hvidovre, Denmark
  8. 8 Department of Surgery, Hospital Tumori, Milan, Italy
  9. 9 Institute of Human Genetics, Newcastle upon Tyne, UK
  10. 10 Department of Genetics, Hospital Pitié-Salpêtrière AP.HP, Paris, France
  11. 11 Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
  12. 12 Institute of Medical Genetics, Cardiff University and Universitiy Hospital of Wales, Cardiff, UK
  13. 13 Department of Clinical Pathophysiology, University of Florence, and Tuscan Tumor Institute, Florence, Italy
  14. 14 Division of Medical Genetics and Department of Biomedicine, University of Children's Hospital, Basel, Switzerland
  15. 15 Department of Clinical Genetics, St George's University of London Hospital, London, UK
  16. 16 Department of Gastroenterology, Konstantopoulio University Hospital, Athens, Greece
  17. 17 Genetic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Scientist Centre, Manchester, UK
  18. 18 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  19. 19 Department of Surgery, Jyvaskyla Central Hospital, Jyvaskyla & Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
  20. 20 Department of Medical Genetics, The Norwegian Radium Hospital University Hospital, Oslo, Norway
  21. 21 Department of Gastroenterology, University Medical Centre Radboud, Nijmegen, The Netherlands
  22. 22 Department of Digestive Surgery, Hospital Saint-Antoine, University Pierre et Marie, Paris, France
  23. 23 Department of Internal Medicine, Universtiy Hospital, Modena, Italy
  24. 24 Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
  25. 25 Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  26. 26 Digestive Oncology Unit, Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
  27. 27 Family Cancer Clinics, St Mark's Hospital, CRUK Cancer Centre, Imperial College London, Harrow, UK
  28. 28 Medical Faculty, Institute of Human Genetics, University of Duesseldorf, Duesseldorf, Germany
  29. 29 Department of Surgery, HELIOS St Josefs Hospital Bochum-Linden (Helios), Bochum, Germany
  1. Correspondence to Professor Dr Hans F A Vasen, Dutch Hereditary Cancer Registry & Department of Gastroenterology, Leiden University Medical Centre, Rijnsburgerweg 10, Leiden 2333 AA, The Netherlands; hfavasen{at}
  • Received 17 December 2012
  • Revised 15 January 2013
  • Accepted 16 January 2013
  • Published Online First 13 February 2013


Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.

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