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Gut 62:1072-1084 doi:10.1136/gutjnl-2012-304353
  • Recent advances in clinical practice

Crohn's disease complicated by strictures: a systematic review

  1. William J Sandborn5
  1. 1Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  2. 2Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  3. 3Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
  4. 4Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  5. 5Division of Gastroenterology, University of California San Diego, La Jolla, California, USA
  1. Correspondence to Dr Florian Rieder, Department of Pathobiology, Lerner Research Institute, NC22, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA; riederf{at}ccf.org
  • Received 21 March 2013
  • Revised 1 April 2013
  • Accepted 3 April 2013
  • Published Online First 26 April 2013

Abstract

The occurrence of strictures as a complication of Crohn's disease is a significant clinical problem. No specific antifibrotic therapies are available. This systematic review comprehensively addresses the pathogenesis, epidemiology, prediction, diagnosis and therapy of this disease complication. We also provide specific recommendations for clinical practice and summarise areas that require future investigation.