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Association of Helicobacter pylori seropositivity with all-cause mortality: fact or fiction?
  1. Palaniappan Manickam1,
  2. Prasad Gunasekaran2,
  3. Rajeev Sudhakar2,
  4. Vikas Veeranna3,
  5. Luis Afonso3
  1. 1 Division of Gastroenterology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA
  2. 2 Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
  3. 3 Division of Cardiology, Wayne State University, Detroit, Michigan, USA
  1. Correspondence to Dr Palaniappan Manickam, Division of Gastroenterology, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48037, USA; Palaniappan.Manickam{at}beaumont.edu

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We read the article by Chen et al with great interest and would like to congratulate them on their findings. Their analysis of the data from the National Health and Nutrition Examination Survey (NHANES III) have shown a lack of association between Helicobacter pylori seropositivity and all-cause mortality in patients more than 40 years of age.1 As there is an existing controversy2–4 in this area, evaluation of other large databases is clinically relevant, particularly if the analyses provides congruent data as in this instance, replicating findings that help consolidate the evidence base in the literature. The …

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