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PTU-199 Proinflammatory Cytokine (Il-8) in Microscopic Enteritis
  1. K Rostami1,
  2. M Rostami Nejad2,
  3. H Asadzadeh2,
  4. M R Zali2
  1. 1Department of Gastroenterology, Luton & Dunstable Hospital NHS Foundation Trust, Luton, Lotun, UK
  2. 2Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic Of

Abstract

Introduction Celiac disease (CD) is an autoimmune disorder that is triggered by an immune response to gluten in genetically predisposed individuals. Interleukin-8 (IL-8) is produced by macrophages, epithelial cells and endothelial cells. Therefore, IL8 has an important role in the innate immune response and associated with inflammation. The aim of this study is to evaluate the elevation of IL8 level in patients with celiac diseasecompare with control group.

Methods Fifty three confirmed treated or untreated celiac disease patients referred to Taleghani hospital, Iran as cases were matched according to age and gender with 300 healthy controls, screened with ELISA to determine the level of IL8.

Results Serum IL8 levels were evaluated in all patients with positive CD compare to healthy control. The minimum level of IL8 in cases was 16.3 and maximum level was 397.7. On the other side the minimum and maximum level of IL8 in controls was 10.3 and 397.7 respectively. The mean level of IL8 in celiac disease patients was 116.8 compare with 84.8 in healthy control. This differences was statistically significant between 2 groups (p = 0.0001).

Conclusion Increased serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with celiac disease. It is the inflammation inherent in gluten sensitivity rather than mucosal atrophy that results in malabsorption and nutrient deficiency. Our findings suggest that higher level of IL8 in patients with celiac disease characterise the higher inflammatory response of this disease in the active phase. The inflammatory response including increasing the level of IL-8 may cause or not damage to the intestinal mucosa but in both cases lead to increased permeability of the intestinal epithelium.

Disclosure of Interest None Declared

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