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Inflammatory bowel disease
PWE-106 Association Study Of Il23R And Atg16L1 Variants In Ibd Moroccan Patients
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  1. N Serbati1,
  2. N Senhaji1,
  3. B Diakite1,
  4. W Badre2,
  5. S Nadifi1
  1. 1Laboratory of Medical Genetics, Medical school of Casablanca - University Ain Chock Hassan II, Center Of Doctoral Sciences “In Health Sciences”
  2. 2Department of Gastro-enterology, CHU Ibn Rochd - Casablanca - Medical school of Casablanca, Casablanca, Morocco

Abstract

Introduction IBD (Crohn’s disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract. Although several studies have tried to explore these diseases, their pathogenesis is still unclear. Recently, CD has been associated with the variants in interleukin 23 receptor (IL23R) and autophagy-related 16-like 1 (ATG16L1) genes. The aim of our study was to assess the frequency of ATG16L1 (T300A) and IL23R (L310P) variants in Moroccan IBD patients and to determine a possible effect of these variants on Disease’s phenotype and clinical course.

Methods we genotyped a group of 96 Moroccan IBD patients and 114 unrelated volunteers for ATG16L1(T300A) and IL23R (L310P) variants.

Results Our results showed no significantly increased risk of Crohn’s disease among individuals carrying the GG genotype or the G allele for the (Thr300Ala) polymorphism, in contrast to the (L310P) polymorphism which confers a protective effect. We also noticed the presence of a positive correlation between Crohn’s disease Type and ATG16L1 polymorphism. For UC, the carriage of the mutated allele in the ATG16L1 gene confers a protective effect.

Conclusion Our results showed a limited role of ATG16L1 and IL23R variants in the Moroccan population

Disclosure of Interest None Declared.

https://doi.org/10.1136/gutjnl-2013-304907.394

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