Introduction VOCs can be utilised as non invasive biomarkers for gastrointestinal diseases such as IBD, as changes in VOCs reflect internal metabolical and pathological processes.
Methods Patients were recruited from outpatients with proven Crohn’s disease(CD N = 41), ulcerative colitis(UC N = 49), IBS(N = 30) and healthy volunteers(N = 47). Disease activity was recorded using Harvey-Bradshaw index(HBI) in CD and simple clinical colitis activity index(SCCAI) in UC. Faecal headspace gas was sampled with SPME and transferred to GC-MS for VOC identification. Statistical analysis was performed on presence or absence and peak area of VOCs.
Results ConclusionFaecal VOCs are capable of distinguishing IBD from non-inflammatory conditions like IBS and healthy.
Disclosure of Interest None Declared
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