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In a study by Sharma et al1 recently published in Gut, high-definition endoscopy and narrow band imaging (NBI) enabled detection of more areas of dysplasia than Seattle protocol. In addition, regular mucosa did not harbour high-grade dysplasia (HGD)/cancer, leading to the suggestion that biopsies could be avoided in those areas.
However, authors stated in the discussion that the routine use of NBI targeted biopsies for detection of HGD/cancer should not be recommended. To highlight this point, we would like report a case of a C10M12 Barrett's oesophagus (BO) patient with two previous macroscopic lesions with HGD and adenocarcinoma resected using multiband mucosectomy (figure 1). In a careful follow-up using the same endoscope as in the reported study,1 no macroscopic lesions were detected and biopsies were performed according to Seattle protocol. The pathological analysis …
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