Gut 63:856 doi:10.1136/gutjnl-2013-305670
  • Editor's quiz: GI snapshot

An unusual cause of weight loss in a young Caucasian man

  1. Giuseppe Mazzella1
  1. 1Gastroenterology Unit, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  2. 2Molecular Pathology Laboratory, Hematopathology Section, S. Orsola-Malpighi Hospital, Department of Specialized Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy
  1. Correspondence to Dr Paolo Cecinato, Gastroenterology Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi University Hospital, Bologna 40138, Italy; paolocecinato{at}
  • Received 15 July 2013
  • Revised 6 August 2013
  • Accepted 8 August 2013
  • Published Online First 4 September 2013

Clinical presentation

A 37-year-old Caucasian male presented to our institution for progressive weight loss and recurrent abdominal pain. An enteral CT performed in another centre showed a diffuse thickening of the duodenal walls suggestive of lymphoma or Crohn’s disease.

Esophagogastroduodenoscopy showed a normal appearance of gastroesophageal mucosa while the duodenal and proximal jejunal mucosa appeared completely covered with pseudo-polypoid lesions with maximum size of 5 mm (figure 1A,B). At the ileocolonoscopy, the colorectal mucosa was diffusely micronodular (figure 1D), while the terminal ileum presented same lesions detected in the duodenum (figure 1C).

Figure 1

Endoscopic view: (A) duodenum, (B) jejunum, (C) ileum, (D) colon.

Enteroscopy confirmed the presence of pseudopolypoid lesions also in the jejunum and ileum, …

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