Article Text

PDF
Use of a preclinical model of pancreas cancer to identify potential candidates for rapalogue therapy
  1. Kenneth K Takeuchi,
  2. Howard C Crawford
  1. Department of Cancer Biology, Mayo Clinic Florida, Jacksonville, Florida, USA
  1. Correspondence to Dr Howard Crawford, Department of Cancer Biology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA; crawford.howard{at}mayo.edu

Statistics from Altmetric.com

The oft-repeated statistics are dismal: pancreatic ductal adenocarcinoma (PDA) has only a 6% 5-year survival rate that has not changed significantly in 30 years and the vast majority of PDA patients perish within 6 months of diagnosis. Several possible reasons contribute to these grim results. PDA is difficult to detect, it is recalcitrant to most targeted treatments and conventional therapies only have a modest effect on survival. Compared with other cancers, PDA was revealed to be remarkably genetically homogenous with 95% or more of PDA harbouring oncogenic mutations in the Kras gene,1 generating hope that finding effective ways of interrupting Kras signalling would increase survival for PDA patients. However, Kras-targeted therapies have proven elusive thus far, leaving its downstream effectors as the most obvious potential targets.

The true genetic heterogeneity of PDA has just begun to be appreciated2 ,3 within a background of the almost universal presence of Kras mutation and the statistically predictable identities of many of the subsequent tumour suppressor mutations that propel its progression and metastasis. Of course, …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Pancreas
    Douglas C Morran Jianmin Wu Nigel B Jamieson Agata Mrowinska Gabriela Kalna Saadia A Karim Amy Y M Au Christopher J Scarlett David K Chang Malgorzata Z Pajak Australian Pancreatic Cancer Genome Initiative (APGI) Karin A Oien Colin J McKay C Ross Carter Gerry Gillen Sue Champion Sally L Pimlott Kurt I Anderson T R Jeffry Evans Sean M Grimmond Andrew V Biankin Owen J Sansom Jennifer P Morton