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Letter
Authors' response: the role of risedronate in osteopenia in Crohn's disease
  1. Ad A van Bodegraven1,
  2. Birgit I Witte2,
  3. Paul Lips3
  4. for the Crohn and Bone Study Group of the Dutch Initiative on Crohn and Colitis (ICC)
  1. 1 Department of Gastroenterology and Hepatology, VUmc, Amsterdam, The Netherlands
  2. 2 Department of Epidemiology and Biostatistics, VUmc, Amsterdam, The Netherlands
  3. 3 Endocrine Section, Department of Internal Medicine, VUmc, Amsterdam, The Netherlands
  1. Correspondence to Dr Ad A van Bodegraven, Department of Gastroenterology and Hepatology, VUmc, PO Box 7057, Amsterdam 1007 MB, The Netherlands; v.bodegraven{at}vumc.nl

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We read with interest the comments of Buchan and Manuel concerning our risedronate intervention trial in osteopenic patients with Crohn's disease.1 ,2

They stipulated that exclusion of patients with vitamin D deficiency limited the significance of the performed study, as this deficiency is frequently observed in Crohn's disease. It is however well known that replenishment of vitamin D (and calcium) in patients with vitamin D deficiency would lead to a rapid improvement of bone density, irrespective of any effect of risedronate. As assessment of a therapeutic effect of the latter was our primary study aim, we …

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