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Recent advances in basic science
MicroRNAs: new players in IBD
  1. R Kalla1,
  2. N T Ventham1,
  3. N A Kennedy1,
  4. J F Quintana2,
  5. E R Nimmo1,
  6. A H Buck2,
  7. J Satsangi1
  1. 1Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
  2. 2Centre for Immunity, Infection and Evolution, Ashworth laboratories, University of Edinburgh, Edinburgh, UK
  1. Correspondence to Professor Jack Satsangi, Gastrointestinal Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; j.satsangi{at}ed.ac.uk

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

  • ULCERATIVE COLITIS
  • INTESTINAL TRACT
  • CROHN'S DISEASE
  • CELLULAR IMMUNOLOGY
  • T LYMPHOCYTES

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

https://doi.org/10.1136/gutjnl-2014-307891

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    • Correction
      Correction
      BMJ Publishing Group Ltd and British Society of Gastroenterology
      Gut 2015; 64 1008-1008 Published Online First: 08 May 2015. doi: 10.1136/gut.2014.307891corr1