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Letter
ATG16L1 contributes to Crohn's disease susceptibility in Koreans: overmuch concern for ethnic difference?
  1. Suk-Kyun Yang1,
  2. Byong Duk Ye1,
  3. Kyuyoung Song2
  1. 1 Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  2. 2 Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  1. Correspondence to Professor Kyuyoung Song, Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 138-736, South Korea; kysong{at}amc.seoul.kr

https://doi.org/10.1136/gutjnl-2014-308242

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    The incidence of Crohn’s disease (CD) increases steadily in Asia, but is still quite low compared with Western countries.1 So far, over 140 susceptibility loci to CD have been identified in Caucasians through genome-wide association studies (GWASs) and meta-analyses.2 Recent GWASs in Korean and Japanese populations identified a few more susceptibility loci, but could not replicate many established CD loci.3 ,4 A Japanese large scale replication study consisting of 1311 cases and 6585 controls could replicate less than half of 71 CD susceptibility loci identified in Caucasians.5 Particularly, it aroused concern that such well-established loci as ATG16L1 and NOD2 have not been replicated. It was unclear whether the lack of association was due to limited statistical power, different linkage disequilibrium (LD) structure, …

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    Footnotes

    • Contributors KS supervised data analysis and wrote the letter; S-KY and BDY supervised all the sample selection.

    • Funding This work was supported by a Mid-career Researcher Program grant through NRF (National Research Foundation of Korea) to KS (2014R1A2A1A09005824) funded by the Ministry of Science, ICT and Future Planning and a Korean Health technology R&D Project grant to S-KY (A120176) from the Ministry of Health & Welfare, the Republic of Korea.

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval Asan Medical Center.

    • Provenance and peer review Not commissioned; internally peer reviewed.