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Original article
Long-term lifestyle changes after colorectal cancer screening: randomised controlled trial
  1. Paula Berstad1,2,
  2. Magnus Løberg3,4,5,
  3. Inger Kristin Larsen2,
  4. Mette Kalager1,3,4,
  5. Øyvind Holme3,4,6,
  6. Edoardo Botteri2,7,
  7. Michael Bretthauer3,4,5,
  8. Geir Hoff1,2,3
  1. 1Department of Research and Development, Telemark Hospital, Skien, Norway
  2. 2Cancer Registry of Norway, Oslo, Norway
  3. 3Department of Health Management and Health Economics, Institute of Health and Society, University of Oslo, Oslo, Norway
  4. 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
  5. 5Department of Gastroenterology, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway
  6. 6Department of Medicine, Sørlandet Hospital, Kristiansand, Norway
  7. 7Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
  1. Correspondence to Dr P Berstad, Cancer Registry of Norway, P.O. box 5313 Majorstuen, 0304 Oslo, Norway; paula.berstad{at}kreftregisteret.no

Abstract

Objective There is uncertainty whether cancer screening affects participant incentives for favourable lifestyle. The present study investigates long-term effects of colorectal cancer (CRC) screening on lifestyle changes.

Design In 1999–2001, men and women drawn from the population registry were randomised to screening for CRC by flexible sigmoidoscopy (‘invited-to-screening’ arm) or to no-screening (control arm) in the Norwegian Colorectal Cancer Prevention trial. A subgroup of 3043 individuals in the ‘invited-to-screening’ and 2819 in the control arm, aged 50–55 years, randomised during 2001 had their lifestyle assessed by a questionnaire at inclusion and after 11 years (42% of cohort). The outcome was 11-year changes in lifestyle factors (body weight, smoking status, physical exercise, selected dietary habits) and in total lifestyle score (0–4 points, translating to the number of lifestyle recommendations adhered to). We compared outcomes in the two randomisation arms and attendees with positive versus negative findings.

Results Total lifestyle scores improved in both arms. The improvement was smaller in the ‘invited-to-screening’ arm (score 1.43 at inclusion; 1.58 after 11 years) compared with the control arm (score 1.49 at inclusion; 1.67 after 11 years); adjusted difference −0.05 (95% CI −0.09 to −0.01; p=0.03). The change in the score was less favourable in screening attendees with a positive compared with negative screening result; adjusted difference −0.16 (95% CI −0.25 to −0.08; p<0.001).

Conclusions The present study suggests that possible unfavourable lifestyle changes after CRC screening are modest. Lifestyle counselling may be considered as part of cancer screening programmes.

Trial registration number NCT00119912.

  • COLORECTAL CANCER SCREENING
  • NUTRITION
  • EPIDEMIOLOGY
  • SCREENING

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