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Original article
Comparing histological activity indexes in UC
  1. Aude Bressenot1,2,
  2. Julia Salleron4,
  3. Claire Bastien2,
  4. Silvio Danese5,
  5. Camille Boulagnon-Rombi6,
  6. Laurent Peyrin-Biroulet1,3
  1. 1Inserm U954, Genetic nutrition and exposure to environmental risks (NGERE), University of Lorraine, Vandoeuvre-lès-Nancy, France
  2. 2Department of Pathology, University Hospital of Lorraine, Vandoeuvre-lès-Nancy, France
  3. 3Department of Hepato-Gastroenterology, University Hospital of Lorraine, Vandoeuvre-lès-Nancy, France
  4. 4Department of biostatistics, Institute de Cancérologie de Lorraine, Vandoeuvre-lès-Nancy, France
  5. 5IBD center, Division of Gastroenterology, Humanitas Clinical and Research hospital, Rozzano, Milano, Italy
  6. 6Department of Pathology, University of Reims et Champagne-Ardenne, Reims, France
  1. Correspondence to Professor Laurent Peyrin-Biroulet, Department of Gastroenterology, Université de Lorraine, Allée du Morvan, Vandœuvre-lès-Nancy 54 511, France; peyrinbiroulet{at}gmail.com

Abstract

Background Assessment of disease activity in UC is important for designing an optimal therapeutic strategy. No single histology score is considered optimum. The aim of this study was to compare intraobserver reproducibility and the interobserver agreement of available histological UC activity indexes.

Methods One hundred and two biopsy specimens (collected between 2003 and 2014) were scored blindly by three pathologists by determining Geboes, Riley, Gramlich and Gupta indexes and global visual evaluation (GVE). Intraobserver reproducibility and interobserver agreements for index and items of index were studied by intraclass correlation coefficient for quantitative parameter and by κ values and Krippendorff index for qualitative parameters. Relationship between indexes was studied by computation of Pearson's and Spearman's correlation coefficients.

Results Geboes, Riley, Gramlich and Gupta indexes and GVE showed good intraobserver reproducibility and a good interobserver agreement. Histological items that showed the best interobserver agreement were ‘erosion/ulceration or surface epithelial integrity’ and ‘acute inflammatory cells infiltrate/neutrophils in lamina propria’. The five scores were strongly correlated.

Conclusions Correlation between indexes is strong. Intraobserver reproducibility and interobserver agreement for all indexes is very good. Histological items that showed the best interobserver agreement are ‘erosion/ulceration’ and ‘acute inflammatory cells infiltrate/neutrophils in lamina propria’.

  • ULCERATIVE COLITIS

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