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PWE-152 Retrospective observational cohort study of gastrointestinal stromal tumours (gists) in a uk regional cancer network
  1. J Wheat,
  2. H Garrod,
  3. L Davies,
  4. WG Lewis
  1. University Hospital of Wales, Cardiff., Cardiff, UK

Abstract

Introduction Gastrointestinal Stromal Tumours (GISTs) are tumours of mesenchymal origin that arise in the GI tract and account for approximately 0.1 to 3% of all gastrointestinal tumours. The aim of this study was to determine the relative incidence, clinical features and treatment outcome of GISTs diagnosed by a regional upper GI cancer network.

Method One hundred and sixty one consecutive patients were identified through the regional upper GI cancer network. The median age was 66 (range 20–91) years; 86 male, 75 female. The primary outcome measure was survival.

Results The anatomical distribution of the tumours was: gastric 74%; small bowel 15%; colorectal 3.8%; oesophageal 2.5%; unknown primary site 4.7%. Ninety-four (58.4%) underwent surgical resection. Thirteen were endoscopic (13.8%). Immunohistochemistry staining was performed on 46.6%, of which 89% were CD117 positive and 49.3% were CD34 positive. Malignant potential was recorded in 45.3% of cases: 12.4% benign; 14.3% low/low-intermediate; 8.7% intermediate; 3.7% high; 6.2% malignant. Overall 5- and 10- year survival was 79% and 53% respectively. Recurrent disease was identified in 6.8% of patients and progressive disease in 7.5%. Rectal and gastric GISTs had the poorest 5- and 10- year survival (p = 0.04). The median size of resected tumours was 5 cm (range 0.4 to 26 cm), and univariate analysis showed an association with survival (Chi214.755, p = 0.005). On multivariable analysis, maximum dimension of resected tumour was the only variable independently associated with survival (HR 1.107, 95% CI 1.035–1.184, p = 0.03).

Conclusion The majority of GISTs diagnosed were upper GI (76.5%). Five- and ten- year survival rates are longer than for other upper GI cancers and clinicians should be aware of this when counselling patients and planning management.

Disclosure of interest None Declared.

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