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PTU-065 The influence of smoking on need for surgery and post-operative outcomes in crohn’s disease
  1. A O’Connor1,
  2. J Taylor1,
  3. F Abid1,
  4. A Crudeli1,
  5. T Clark1,
  6. N Scott2,
  7. PJ Hamlin1,
  8. AC Ford1
  1. 1Gastroenterology
  2. 2Histopathology, St. James’s University Hospital, Leeds, UK

Abstract

Introduction Up to 70% of patients with Crohn’s disease (CD) may require surgery at some point in their lives and it is estimated 39% may require several surgeries. Indications for surgery include failure of medical treatment, bowel obstruction, fistula or abscesss formation. The most common surgical procedure is resection. Smoking is a recognised risk factor for requiring surgery in Crohn’s and also predicts post-operative recurrence.

Method We aimed to examine the effect of tobacco smoking on the risk for surgery and it’s influence on post-operative outcomes in patient with CD. We performed a retrospective analysis by initially identifying cases by interrogating the pathology database over a five year period from 2009 to 2013 and further data was then extracted by chart review.

Results 152 resections took place over the study period, 6 of these had taken place on children and these were not analysed for smoking history. Median follow-up was 32 months (range 1 to 69 months). 31.5% (n = 46) of adults were active smokers at time of surgery. Among those having repeat resections 24.1% were active smokers. Smokers were more likely to have required emergency surgery than non-smokers (34.8% vs 30.0%). Median disease duration prior to surgery (among patients having first surgery) was shorter in the smoking group (2.5 vs 4 years). Smokers were more likely to have penetrating disease (32% vs 25.5%). The rate of steroid-free, further resection-free survival at end of follow up was higher for non-smokers (66% vs 63.0%). 68 patients had colonoscopies during follow-up, in 4 cases a Rutgeerts score could not be ascertained from the report. 43.8% (7/16) of smokers had endoscopic recurrence with Rutgeerts score i2 or greater compared to 45.8% (22/48) of non-smokers.

Conclusion Compared to the background rate of smoking among adults in the UK (18.7%), smokers are over-represented in this CD surgery cohort. In this small, retrospective cohort smokers were more likely to have penetrating disease, come to surgery sooner and require emergency surgery than non-smokers. Outcomes were broadly similar for smokers and non-smokers with a minor benefit for achieving steroid free, further resection-free survival in the non-smoking group and slightly less endoscopic recurrence among smokers. The lower rate of smoking among those having repeat resections compared to first resections may indicate that a CD resection is a motivating factor to give up smoking.

Disclosure of interest None Declared.

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