Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Alexandra Montagner; Arnaud Polizzi; Edwin Fouché; Simon Ducheix; Yannick Lippi; Frédéric Lasserre; Valentin Barquissau; Marion Régnier; Céline Lukowicz; Fadila Benhamed; Alison Iroz; Justine Bertrand-Michel; Talal Al Saati; Patricia Cano; Laila Mselli-Lakhal; Gilles Mithieux; Fabienne Rajas; Sandrine Lagarrigue; Thierry Pineau; Nicolas Loiseau; Catherine Postic; Dominique Langin; Walter Wahli; Hervé Guillou

doi:10.1136/gutjnl-2015-310798

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Hepatology

Original article

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

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Alexandra Montagner INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Arnaud Polizzi INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Edwin Fouché INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Simon Ducheix INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Yannick Lippi INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Frédéric Lasserre INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Valentin Barquissau INSERM UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France PubMed articles Google scholar articles
Marion Régnier INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Céline Lukowicz INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Fadila Benhamed INSERM U1016, Cochin Institute, Paris, France CNRS UMR 8104, Paris, France University of Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articles Google scholar articles
Alison Iroz INSERM U1016, Cochin Institute, Paris, France CNRS UMR 8104, Paris, France University of Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articles Google scholar articles
Justine Bertrand-Michel INSERM UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France PubMed articles Google scholar articles
Talal Al Saati INSERM/UPS-US006/CREFRE, Service d'Histopathologie, CHU Purpan, Toulouse, France PubMed articles Google scholar articles
Patricia Cano INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Laila Mselli-Lakhal INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Gilles Mithieux INSERM U855, University of Lyon, Lyon, France PubMed articles Google scholar articles
Fabienne Rajas INSERM U855, University of Lyon, Lyon, France PubMed articles Google scholar articles
Sandrine Lagarrigue INRA UMR1348 Pegase, Saint-Gilles, France Agrocampus Ouest, UMR1348 Pegase, Rennes, France Université Européenne de Bretagne, France PubMed articles Google scholar articles
Thierry Pineau INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Nicolas Loiseau INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles
Catherine Postic INSERM U1016, Cochin Institute, Paris, France CNRS UMR 8104, Paris, France University of Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articles Google scholar articles
Dominique Langin INSERM UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France Laboratory of Clinical Biochemistry, Toulouse University Hospitals, Toulouse, France PubMed articles Google scholar articles
Walter Wahli INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, Switzerland PubMed articles Google scholar articles
Hervé Guillou INRA UMR1331, ToxAlim, University of Toulouse, Toulouse, France PubMed articles Google scholar articles

Correspondence to Dr Hervé Guillou, INRA UMR1331, ToxAlim, Chemin de Tournefeuille, Toulouse 31027, France; herve.guillou{at}toulouse.inra.fr or Prof. Walter Wahli Lee Kong Chian School of Medicine Nanyang Technological University The Academia, 20 College Road, Singapore 169856; walter.wahli{at}ntu.edu.sg

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Montagner A, Polizzi A, Fouché E, et al

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Gut 2016;65:1202-1214.

Publication history

Received September 25, 2015
Revised December 28, 2015
Accepted January 4, 2016
First published February 1, 2016.

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October 26, 2017

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