Article Text

PDF
PTH-090 Eosinophilia of The Gut. Is It Inflammatory Bowel Disease?
  1. S Chetcuti Zammit1,
  2. J Gauci2,
  3. M Cachia2,
  4. K Sapiano2,
  5. P Ellul1
  1. 1Gastroenterology
  2. 2Medicine, Mater Dei Hospital, Msida, Malta

Abstract

Introduction Eosinophilic gastroenteropathy (EG) is an uncommon condition. The causes for this can be numerous as well as non-specific. Inflammatory Bowel Disease (IBD) is one of the causes. It can also be a manifestation of atopy. The aims of our study were (1) to determine if patients who present with eosinophilia of the gut are eventually diagnosed with IBD and (2) to determine if patients with EG have a higher rate of atopic conditions namely, asthma, allergic rhinitis and eczema.

Methods Adult patients who had gastrointestinal eosinophilia were identified through the histopathology department and recruited. Their clinical case notes were reviewed. Patients were interviewed and asked questions regarding asthma, allergic rhinitis and eczema.

Results 66 patients (39 females; mean age 48.4 SD±18.5) were recruited. The mean eosinophilic count was 0.353 SD±1.08 (normal range 0.10–0.70 x 10 9/L).The commoner clinical presentations were diarrhoea (42.4%), abdominal pain (33.3%) and weight loss (8.2%). The parts of the gastrointestinal tract where eosinophilic infiltration was present were: stomach (6), colon (37), small bowel (SB) (7), SB and colon (12), oesophgeal (1), oesophageal and colon (2), stomach, SB and colon (1).25.8% of patients were later diagnosed with IBD (10 patients - ulcerative colitis, 6 patients – Crohn’s disease and 1 patient had indeterminate colitis). No other secondary causes for GE were present in the rest of the patients and their symptoms resolved without any medical intervention.The prevalence of allergic rhinitis (41.3%) (p < 0.002) and eczema (26.1%)(p < 0.001) with GE were higher than that of the general population. Although asthma (17.4%) was more frequently present in patients with GE than the population, this did not reach statistical significance (p < 0.62).

Conclusion A high proportion of patients (25.8%) with GE was subsequently diagnosed with IBD. Asthma, eczema and allergic rhinitis in patients with underlying EG are higher than in the general population. Most of the patients had transient GI symptoms that later resolved. Thus, GE may represent an atopic condition of the gut or a response to a food allergen.

Disclosure of Interest None Declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.