Article Text

PDF
PTU-072 Discontinuation of Infliximab in Patients with Ulcerative Colitis is Associated with Increased Risk of Relapse: A Multinational Retrospective Cohort Study
  1. G Fiorino1,
  2. PN Cortes2,
  3. P Ellul3,
  4. C Felice4,
  5. P Karatzas5,
  6. M Silva6,
  7. PL Lakatos7,
  8. F Bossa8,
  9. S Sebastian9,
  10. B Ungar10,
  11. F Furfaro11,
  12. K Karmiris12,
  13. KH Katsanos13,
  14. M Muscat3,
  15. D Christodoulou13,
  16. G Maconi14,
  17. U Kopylov10,
  18. F Magro6,
  19. GJ Mantzaris5,
  20. A Armuzzi4,
  21. MM Boscà-Watts2,
  22. S Ben-Horin10,
  23. S Bonovas11,
  24. S Danese11
  1. 1IBD Centre, Humanitas Research Hospital, Milan, Italy
  2. 2IBD Unit, Valencia University Hospital, Valencia, Spain
  3. 3Division of Gastroenterology, Mater Dei Hospital, Malta, Malta
  4. 4IBD Unit, Gemelli Hospital Catholic University, Rome, Italy
  5. 5Department of Gastroenterology, Evangelismos Hospital, Athens, Greece
  6. 6Department of Gastroenterology, Hospital de São João, Porto, Portugal
  7. 71st Department of Internal Medicine, Semmelweiss University, Budapest, Hungary
  8. 8Unità di Gastroenterologia ed Endoscopia Digestiva, Ospedale Casa Sollievo della Sofferenza, M, Italy
  9. 9IBD Unit, Department of Gastroenterology, Hull 7 East Yorkshire NHS Trust, Hull, UK
  10. 10Department of Gastroenterology, Sheba Medical Centre, Tel Hashomer, Sackler School of Medicine, Tel-Aviv, Israel
  11. 11IBD Centre, Department of Gastroenterology, Humanitas Research Hospital, Milan, Italy
  12. 12Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Crete
  13. 13Division of Gastroenterology, School of Health Sciences, University of Ioannina, Ioannina, Greece
  14. 14Division of Gastroenterology, Luigi Sacco University Hospital, Milan, Italy

Abstract

Introduction Efficacy and safety of infliximab in ulcerative colitis (UC) is well-established. We conducted a multicenter retrospective cohort study across 7 European countries, and Israel, to examine whether infliximab discontinuation can be considered for patients who achieve sustained remission.

Methods The disease course of patients who discontinued infliximab was compared against that of patients who continued scheduled treatment (control group). We examined the incidence rates of relapse, hospitalisation and colectomy, the comparative effectiveness of different therapeutic strategies after discontinuation, and assessed the rates of response, remission and adverse effects after infliximab re-initiation. Statistical analyses employed time-to-event methods

Results In total, 193 patients were included, 111 discontinued infliximab. The incidence rate of relapse was significantly higher after discontinuation (23.3 per 100 person-years) as compared to the control group (7.2 per 100 person-years) both in univariable (log-rank p < 0.001; hazard ratio [HR]: 3.41, 95% CI: 1.88–6.20) and multivariable analysis (HR: 3.70, 95% CI: 2.02–6.77). Rates of hospitalisation and colectomy were not different between the groups. Thiopurines appeared to be the best treatment option after infliximab discontinuation (incidence of relapse: 15.0 per 100 person-years for thiopurines, 27.4 per 100 person-years for thiopurines plus aminosalicylates, and 31.2 per 100 person-years for aminosalicylates alone, log-rank p = 0.032). Response was regained in 77.1% and remission in 51.4% of patients who re-initiated infliximab. However, 17.1% suffered infusion reactions, and 17.1% reported other adverse events

Conclusion Infliximab discontinuation in UC patients with sustained clinical remission is associated with increased risk of relapse. Treatment re-initiation is effective and safe.

Disclosure of Interest G. Fiorino Consultant for: MSD, AbbVie, Takeda, Janssen, Mundipharma, Sandoz, Pfizer, P. Cortes: None Declared, P. Ellul Grant/research support from: MSD, AbbVie, C. Felice Consultant for: MSD, AbbVie, P. Karatzas: None Declared, M. Silva: None Declared, P. Lakatos Grant/research support from: MSD, AbbVie, Hospira, Consultant for: MSD, AbbVie,Celltrion, EGIS, Falk Pharma GmbH, Ferring, Genentech, Hospira, F. Bossa Consultant for: MSD, Abbvie, Mundipharma, and Takeda, S. Sebastian Grant/research support from: MSD, AbbVie, Speaker bureau with: MSD, B. Ungar: None Declared, F. Furfaro: None Declared, K. Karmiris Consultant for: MSD, AbbVie, Takeda, K. Katsanos: None Declared, M. Muscat: None Declared, D. Christodoulou: None Declared, G. Maconi: None Declared, U. Kopylov Consultant for: Janssen, Abbvie, Takeda and CTS, F. Magro: None Declared, G. Mantzaris: None Declared, A. Armuzzi Grant/research support from: MSD, Consultant for: Abbvie, Celltrion, Ferring, Hospira, Janssen, Lilly, MSD, Mundipharma, Pfizer, Sofar, Takeda, M. M. Boscà-Watts: None Declared, S. Ben-Horin Grant/research support from: AbbVie and Celltrion, Consultant for: AbbVie, Celltrion, Janssen, Takeda and Schering-Plough, S. Bonovas: None Declared, S. Danese Consultant for: Schering-Plough, Abbott Laboratories, Merck, UCB-pharma, Ferring, Cellerix, Millenium Takeda, Nycomed, Pharmacosmos, Actelion, Danone, Alpha Wasserman, Genentech, Grunenthal, Pfizer, Astra Zeneca, Novo Nordisk, Cosmo Pharmaceuticals, Vifor, and Johnson & Johnson, Speaker bureau with: Schering-Plough, Abbott Laboratories, Merck, UCB-pharma, Ferring, Cellerix, Millenium Takeda, Nycomed, Pharmacosmos, Actelion, Danone, Alpha Wasserman, Genentech, Grunenthal, Pfizer, Astra Zeneca, Novo Nordisk, Cosmo Pharmaceuticals, Vifor, and Johnson & Johnson

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.