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Letter
The appropriate dose and cost of iron replacement therapy in patients with IBD
  1. Rui Dong,
  2. Shan Zheng,
  3. Gong Chen
  1. Department of Pediatric Surgery, Children's Hospital of Fudan University, and Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, China
  1. Correspondence to Dr Rui Dong, Department of Pediatric Surgery, Children's Hospital of Fudan University, and Key Laboratory of Neonatal Disease, Ministry of Health, 399 Wan Yuan Road, Shanghai 201102, China; dongrui_1982{at}126.com

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We read with great interest the article by Lee et al,1 who performed an open-label clinical trial to compare the effects of per os (PO) versus intravenous iron replacement therapy (IRT) for iron deficiency in patients with IBD. They concluded that IRT in patients with iron deficiency or anaemia induced significant shifts in bacterial community structure and metabolite landscape in faeces, and PO iron therapy affected the presence of specific molecular bacterial species. These are impressive findings that raise two important issues.

First, Lee et al 1 enrolled participants with Crohn’s disease (n=31), UC (n=22) and non-IBD control anaemic subjects (n=19) for IRT intervention 3 months PO iron sulfate or intravenous iron sucrose. PO participants …

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