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Letter
Reply to letter to the editor of Gut by Dickson and Cox
  1. Jacqueline M Lankelma1,
  2. Tim J Schuijt1,
  3. W Joost Wiersinga2
  1. 1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  2. 2Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  1. Correspondence to Dr W J Wiersinga, Department of Medicine, Division of Infectious Diseases, Academic Medical Center, Meibergdreef 9, room G2-132, Amsterdam 1054BR, The Netherlands; w.j.wiersinga{at}amc.uva.nl

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Dear editor,

We are thankful for the letter of Drs Dickson and Cox in response to our paper on the effect of the intestinal microbiota on host responses during pneumococcal pneumonia.1 We do agree that we cannot rule out that the antibiotics we used in our experiments could have influenced the microbiota in the airways and we do underwrite the importance of studying local host–microbe interactions within the respiratory tract during pneumonia. However, some points need to be addressed.

The relative importance of the microbiota of the lower airways, the area where alveolar macrophages reside, is a matter of debate. …

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