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Contributors MD had the original idea, and designed the study together with AF; SW, AA, LE and LA collected material, characterised the study subjects and acquired data; F-AH, AF and JFB performed microbiota sequencing; data analysis and interpretation were done by FH, MB, FB, JR and MD. FH, MD and JR drafted the manuscript with critical revision from all authors.
Funding Supported by funds from the Swedish Research Council (Vetenskapsradet) to MD; European Union Seventh Framework Programme (FP7/2007-2013, grant number 262055, ESGI) to MD and AF; Iranian ministry of health and medical education to FH.
Competing interests None declared.
Ethics approval Karolinska Institutet, Stockholm, Sweden.
Provenance and peer review Not commissioned; internally peer reviewed.