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Experimental infection of rabbits with genotype 3 hepatitis E virus produced both chronicity and kidney injury
  1. Lin Wang1,
  2. Junke Xia1,
  3. Ling Wang1,
  4. Youchun Wang2
  1. 1Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
  2. 2Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China
  1. Correspondence to Dr Ling Wang, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China; lingwang{at}bjmu.edu.cn Dr Youchun Wang, Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, No 2 Tiantanxili, Beijing 100050, China; wangyc{at}nifdc.org.cn

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Dear Editor,

We read with great interest the elegant work of Sayed et al,1 which established a mouse model for chronic hepatitis E virus (HEV) infections. The study showed that mice with humanised livers could be infected with both HEV-1 and HEV-3 and develop a chronic viral infection. The establishment of this model meets the urgent need for a research animal model to study chronic hepatitis E infection as increasing cases of such infections have been reported in immunocompromised patients.2 We have recently reported on a chronic hepatitis E case caused by HEV-4 in a woman with nephritic syndrome.3 HEV RNA and antigen were detected in the patient's urine and HEV RNA-positive urine successfully induced infection in Cynomolgus monkeys.3 We agree with the claim made by Sayed et al1 that their model may allow the unravelling of the potential relationship between HEV infection and kidney disease. However, this will require …

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