Article Text

51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population
  1. FM Jones,
  2. O McCarthy,
  3. A Lavelle,
  4. P Twomey,
  5. H Mulcahy,
  6. G Cullen,
  7. J Sheridan,
  8. GA Doherty
  1. Central for Colorectal Disease, St Vincent’s University Hospital School of Medicine, University College Dublin, Ireland


Background Low levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.

Aim Ireland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters have been mixed.

Method We conducted a single centre retrospective study in our hospital from Jan 2015- June 2016. The aim was to assess the prevalence of vitamin D deficiency in IBD and non-IBD cohorts and to assess the impact of vitamin D deficiency on disease activity in IBD. Patients were separated into 4 groups: Crohns Disease (CD), Ulcerative Colitis (UC), general gastroenterology (GI) and general medical (non-GI). Basic demographic data disease specific information was recorded. Vitamin D deficiency was defined as <30 nmol/L.

Results 395 patients were studied: 157 CD, 70 UC, 75 GI and 93 non-GI. IBD patients were found to have high rates of Vitamin D deficiency (33% levels<30 nmol/L). Serum Vitamin D did not differ significantly between groups with mean values of 44.9 nmol/L (CD), 50.7 nmol/L(UC), 45.4 nmol/L(GI) and 45.6 nmol/L(non-GI). Symptommatic IBD patients had significantly higher mean CRP levels (8.6 mg/L) versus those who were asymptomatic (3.5 mg/L), (p<0.001). 35% of IBD patients who were symptomatic had vitamin D deficiency compared with 27% of those who were asymptomatic.

Conclusions We found very high rates of vitamin D deficiency in both IBD and non-IBD patients. Absolute levels did not differ significantly between groups. This may be accounted for by high overall prevalence of Vitamin D deficiency in this population or by confounders in the control population.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.