Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

E Hessmann; M S Patzak; L Klein; N Chen; V Kari; I Ramu; T E Bapiro; K K Frese; A Gopinathan; F M Richards; D I Jodrell; C Verbeke; X Li; R Heuchel; J M Löhr; S A Johnsen; T M Gress; V Ellenrieder; A Neesse

doi:10.1136/gutjnl-2016-311954

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Pancreas

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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

Authors

E Hessmann Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
M S Patzak Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
L Klein Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
N Chen Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
V Kari Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany PubMed articles Google scholar articles
I Ramu Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
T E Bapiro Cancer Research UK Cambridge Institute, The University of Cambridge, Li Ka Shing Centre, Cambridge, UK Oncology iMED DMPK AstraZeneca UK Ltd, HODGKIN C/o B310 Cambridge Science Park, Cambridge, UK PubMed articles Google scholar articles
K K Frese The University of Manchester, Cancer Research UK Manchester Institute, Manchester, UK PubMed articles Google scholar articles
A Gopinathan Cancer Research UK Cambridge Institute, The University of Cambridge, Li Ka Shing Centre, Cambridge, UK PubMed articles Google scholar articles
F M Richards Cancer Research UK Cambridge Institute, The University of Cambridge, Li Ka Shing Centre, Cambridge, UK PubMed articles Google scholar articles
D I Jodrell Cancer Research UK Cambridge Institute, The University of Cambridge, Li Ka Shing Centre, Cambridge, UK Department of Oncology, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
C Verbeke Department of Pathology, Karolinska University Hospital, Stockholm, Sweden Department of Pathology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway PubMed articles Google scholar articles
X Li Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
R Heuchel Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
J M Löhr Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
S A Johnsen Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany PubMed articles Google scholar articles
T M Gress Department of Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany PubMed articles Google scholar articles
V Ellenrieder Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles
A Neesse Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany PubMed articles Google scholar articles

Correspondence to Dr Albrecht Neesse, Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany; albrecht.neesse{at}med.uni-goettingen.de

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Hessmann E, Patzak MS, Klein L, et al

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

Gut 2018;67:497-507.

Publication history

Received March 30, 2016
Revised November 1, 2016
Accepted November 23, 2016
First published January 10, 2017.

Online issue publication

June 23, 2018

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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