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Response to: ‘Prognosis of immune-tolerant phase chronic hepatitis B’ by Chu and Liaw
  1. Gi-Ae Kim1,
  2. Young-Suk Lim2
  1. 1 Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  2. 2 Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  1. Correspondence to Professor Young-Suk Lim, Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; limys{at}amc.seoul.kr

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We appreciate the interest given to our article1 by Chu and Liaw.2

Determining disease phases of patients with chronic hepatitis B (CHB) is essential for assessing patient prognosis and need for treatment. Distinguishing between the immune-tolerant and immune-active phases among patients with hepatitis B e antigen (HBeAg)-positive CHB is best determined by identifying significant necroinflammation and/or fibrosis through liver biopsy. However, given the dynamic nature of CHB and the risks and costs of repeated liver biopsy, this recommendation may not always be realistic, especially …

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