Dear Sir, We report here an instance of drug-related thrombocytopenia associated to infliximab and later on with adalimumab in a patient with Crohn disease (CD). A 42-year-old woman was diagnosed of colonic CD with perianal fistulae lesions (PDAI = 11). She was treated with metronidazole and azathioprine. After two months, the patient remained symptomatic and three infusions with infliximab (monoclonal antibody against tumor necrosis factor α (TNF-α)) at a dose of 5mg/kg were administered at 0, 2 and 6 weeks. Symptoms decreased and improvement was noted (PDAI = 2).
- crohn disease