Hepatitis C infection is considered the leading cause of chronic liver disease in Egypt. HCV genotype 4 is the predominant genotype in the Middle East including Egypt1. A striking feature of HCV infection is its association with fat accumulation within hepatocytes 2; which is defined by either the presence of hepatic steatosis with or without steatohepatitis3. Hepatic steatosis has been reported in 30-70% of patients with HCV infection even when the most common causes of steatosis are excluded4. A causal relationship between infection with HCV genotype 3 and incidence of hepatic steatosis have been elicited5. In Egypt, the true prevalence of nonalcoholic fatty liver disease (NAFLD) is unknown among HCV patients who are commonly infected with genotype 4. Our aim is to determine prevalence of steatosis in patients infected with HCV genotype 4, and correlate steatosis with risk factors as obesity, Type II diabetes mellitus, hypertriglyceridemia and the impact of steatosis on necroinflammatory injury and fibrosis score.
- genotype 4