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Low adherence to colonoscopy in the screening of first- degree relatives of patients with colorectal cancer
  1. Luis Bujanda (castro{at}medynet.com)
  1. Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain
    1. Cristina Sarasqueta
    1. Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain
      1. Leire Zubiaurre
      1. Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain
        1. Carmen Muñoz
        1. San Eloy Hospital, Baracaldo, Spain
          1. Araceli Sanchez
          1. San Eloy Hospital, Baracaldo, Spain
            1. Cristina Martín
            1. l'esperit Sant de Santa Coloma de Gramanet Hospital, Spain
              1. Llucia Tito
              1. l'esperit Sant de Santa Coloma de Gramanet Hospital, Spain
                1. Cristina Piñol
                1. Clinic Hospital-CIBEREHD, Barcelona, Spain
                  1. Antoni Castells
                  1. Clinic Hospital-CIBEREHD, Barcelona, Spain
                    1. Xavier Llor
                    1. Trias i Pujol Hospital, Badalona, Spain
                      1. Rosa María Xicola
                      1. Trias i Pujol Hospital, Badalona, Spain
                        1. Elisenda Pons
                        1. Trias i Pujol Hospital, Badalona, Spain
                          1. Juan Clofent
                          1. Meixoeiro Hospital, Pontevedra, Spain
                            1. Luisa de Castro
                            1. Meixoeiro Hospital, Pontevedra, Spain
                              1. Jaime Cuquerella
                              1. General Hospital, Valencia, Spain
                                1. Enrique Medina
                                1. General Hospital, Valencia, Spain
                                  1. Ana Gutierrez
                                  1. General Hospital, Alicante, Spain
                                    1. Rodrigo Jover
                                    1. General Hospital, Alicante, Spain
                                      1. Juan I Arenas
                                      1. Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain
                                        1. A Cosme
                                        1. Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain

                                          Abstract

                                          Objetive: Colonoscopy is one of the methods of choice for screening relatives of patients with colorectal cancer. To evaluate the rate of adherence to colonoscopy in first-degree relatives of patients with colorectal cancer and describe the lesions found.

                                          Design: We conducted a prospective, cross- sectional, multicenter, nationwide study. The study population was composed of first-degree relatives of patients with colorectal cancer selected randomly from the EPICOLON study. Seventy-four index patients were included. These had 342 living first-degree relatives (parents, siblings, and children), of whom we interviewed 281.

                                          Results: The adherence rate was 38% (107/281). Adherence was greater in families with a higher degree of familial aggregation for colorectal cancer (88,9% for Amsterdam vs. 33,3% for Bethesda and sporadic cancer) (P<0.05), an index patient aged under 65 years (60 percent for patients <65 years vs. 32.9 percent for patients ≥65 years; P<0.05), and an index patient who was female (46.2 percent for women vs. 31 percent for men; P=0.28). Adherence was also greater in relatives under 65 years (54 percent in patients <65 years vs. 18 percent in patients ≥65 years; P=0.05), in female relatives (49 percent in female relatives vs. 27.3 percent in male relatives) and in siblings and children (40% in sibling and children vs. 13% in parents; P<0.05). Lesions were found in 26% (28/107) of the study population. Nine (8.4 percent) individuals had a total of 18 advanced lesions.

                                          Conclusions: These results indicate that adherence to colonoscopy in our population of first- degree relatives was low, and was more frequently associated with a higher degree of familial aggregation, a relative age of under 65 years, a sibling or offspring relationship, and female sex.

                                          • Adherence
                                          • colonoscopy
                                          • colorectal cancer
                                          • first-degree
                                          • screening

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