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APCmin tumors need a SPARC
  1. Alex Gregorieff (gregorieffa{at}niob.knaw.nl)
  1. Hubrecht Laboratory, The Netherlands Institute for Developemental Biology, Netherlands
    1. Hans Clevers (clevers{at}niob.knaw.nl)
    1. Hubrecht Laboratory, The Netherlands Institute for Developemental Biology, Netherlands

      Abstract

      The interaction between cancer cells and their microenviroment strongly influences growth and invasiveness of neoplasia. In this issue of Gut, a new study identifies the extracellular matrix (ECM) component, SPARC, as a critical determinant of tumor burden in the APCmin/+ model of intestinal cancer.

      • APCmin
      • Colorectal cancer
      • extracellular matrix

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