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Opportunistic infections attributed to immunomodulator agents and tumour necrosis factor antagonists in patients with inflammatory bowel disease: prevention and diagnosis
  1. Nathalie Viget (nviget{at}ch-tourcoing.fr)
  1. Service des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, France
    1. Gwenola Vernier-Massouille
    1. Service d’Hépato-gastroentérologie, Hôpital Claude Huriez, CHRU de Lille, France
      1. Dominique Salmon-Céron
      1. Service des Maladies Infectieuses, Université Paris V, Faculté Cochin, France
        1. Yazdan Yazdanpanah
        1. Service des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, France
          1. Jean-Frederic Colombel (jfcolombel{at}chru-lille.fr)
          1. Service d’Hépato-gastroentérologie, Hôpital Claude Huriez, CHRU de Lille, France

            Abstract

            Because of the increasing use of immunosuppressive and biologic drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD). Consequently, improvement of health care workers’ knowledge of this domain is urgent. In this review, the authors list the preventive measures that would help to reduce the rate of opportunistic infections in patients with IBD, and consider the management of situations frequently confronting clinicians. In the absence of national and international recommendations, the information given here should help clinicians to optimize patient outcomes.

            • factor antagonists
            • immunomodulator agents
            • inflammatory bowel disease
            • opportunistic infection
            • tumor necrosis

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