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Autophagy as an important process in gut homeostasis and CD pathogenesis.
  1. Ramnik Xavier (xavier{at}molbio.mgh.harvard.edu)
  1. Massachusetts General Hospital, Harvard Medical School, United States
    1. Alan Huett (ahuett{at}partners.org)
    1. Massachusetts General Hospital, Harvard Medical School, United States
      1. John D Rioux (rioux{at}broad.mit.edu)
      1. Université de Montréal and the Montreal Heart Institute, Canada

        Abstract

        Recent genome-wide association studies in Crohn's disease have identified genetic variation within two genes involved in a biological process known as autophagy. These genetic findings reveal an important role for autophagic processes in both gut homeostasis and in the development of chronic inflammation of the gastrointestinal tract.

        • association
        • autophagy
        • immunity
        • inflammation
        • inflammatory bowel diseases

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