Article Text

other Versions

PDF
Role of dietary fibers, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats
  1. Hiroshi Satoh (h_satoh{at}muses.tottori-u.ac.jp)
  1. Faculty of Agriculture, Tottori University, Japan
    1. Sachiko Shiotani
    1. Faculty of Agriculture, Tottori University, Japan
      1. Noriko Otsuka
      1. Faculty of Agriculture, Tottori University, Japan
        1. Kana Hatao
        1. Faculty of Agriculture, Tottori University, Japan
          1. Seigi Nishimura
          1. Faculty of Agriculture, Tottori University, Japan

            Abstract

            Background: Recent advances in endoscopy have revealed that NSAIDs often cause ulcers in the human small intestine. However, the mechanism of intestinal ulcer formation is still unclear.

            Aims: The role of dietary fiber (DF), intestinal motility and leukotrienes (LTs) in the formation of small intestinal ulcers induced by indomethacin (IND) was investigated in cats.

            Methods: Several types of diets containing DF at various percentages were given to animals twice daily during the experiment. IND was administered orally once daily after the morning meal for 3 days, and the area of mucosal lesions in the intestine was measured. Gastrointestinal motility was measured using a telemetry system in conscious cats implanted with force transducers.

            Results: In cats fed regular dry food containing 2.8% DF, IND (3 mg/kg, p.o.) significantly increased the motility of the lower half of the small intestine and produced many severe lesions; the total lesion area was 7.7±2.0 cm2 (n=5). The lesions were markedly decreased with the low (0.4%)-DF diet and increased with the high (7.2%)-DF diet. The lesion area was 0.1±0.1 cm2 (P<0.05) and 18.2±4.1 cm2 (P<0.05), respectively. Supplementation with insoluble DF (6% cellulose), but not soluble DF (pectin), in the low-DF diet increased the lesion area significantly. The hypermotility and lesion formation in the small intestine induced by IND were significantly (P<0.05) inhibited by AA-861 (a 5-lipoxygenase inhibitor), pranlukast (a LT receptor antagonist), or atropine.

            Conclusions: Insoluble DF, intestinal hypermotility, leukotrienes and cholinergic pathways are implicated in the pathogenesis of small intestinal ulcers induced by NSAIDs.

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

            Linked Articles

            • Digest
              BMJ Publishing Group Ltd and British Society of Gastroenterology